Anti-ZBED1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

Features and Benefits

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Immunogen

ZBED1 antibody was raised against a 15 amino acid peptide from near the center of human ZBED1.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500027.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Target description

ZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation. RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in the inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 also plays a role in cell proliferation in human cells. At least 22 ribosomal proteins (RPs) possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression. Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, and this self-association is required for nuclear localization and DNA binding. This antibody is predicted to have no cross-reactivity to ZBED2 or ZBED3.